阿昔洛韦片

【药品名称】 通用名称：阿昔洛韦片
英文名称：Aciclovir Tablets
汉语拼音：Axiluowei Pian
【成 份】本品主要成份为阿昔洛韦。
【性 状】本品为白色片。

　　HUAXUEMINGCHENG：9-(2-QIANGYIYANGJIAJI)NIAOPIAOLING

　　FENZISHI：C8H11N5O3

　　FENZILIANG：225.21

　　【SHIYINGZHENG】BENPINSHIYONGYUZHILIAOXIALIEJIBING：

　　1、JIXINGDAIZHUANGPAOZHEN：YONGYUZHILIAOJIXINGDAIZHUANGPAOZHEN。

　　2、SHENGZHIQIPAOZHEN：YONGYUZHILIAOCHUFAHEFUFADESHENGZHIQIPAOZHEN。

　　3、SHUIDOU：YONGYUZHILIAOSHUIDOU。

　　【GUIGE】0.1g

　　【YONGFAYONGLIANG】KOUFU，JILIANGRUXIA：

　　(YI)、CHANGYONGJILIANG

　　1、JIXINGDAIZHUANGPAOZHEN：CHENGRENMEICI200-800mg，MEI4XIAOSHI1CI，YIRI5CI，LIANYONG7-10RI。

　　2、SHENGZHIQIPAOZHEN：

　　CHUFASHENGZHIQIPAOZHEN：CHENGRENMEICI200mg，MEI4XIAOSHI1CI，YIRI5CI，LIANYONG10RI。

　　MANXINGFUFAXINGSHENGZHIQIPAOZHEN：CHENGRENMEICI200-400mg，MEIRI2CI，CHIXUZHILIAO4-6GEYUEHUO12GEYUE，JINXINGZAIPINGJIA。GENJUZAIPINGJIAJIEGUO，XUANZEMEICI200mg、MEIRI3CI，HUOMEICI200mg、MEIRI5CIDEZHILIAOFANGAN。WEIZHILIAOGUODESHENGZHIQIPAOZHENDEFAZUOPINLVHEYANZHONGXINGKENENGHUISUISHIJIANBIANHUA。ZHILIAO1NIANHOU，YAODUISHENGZHIQIPAOZHENGANRANHUANZHEDEFAZUOPINLVHEYANZHONGXINGJINXINGZAIPINGJIA，YIQUEDINGSHIFOUJIXUSHIYONGBENPINZHILIAO。

　　JIANXIEXINGZHILIAO：YINGZAIFUFAXINGZHENGZHUANGCHUQIJIYIJISHIZHILIAO，CHENGRENMEICI200mg，MEI4XIAOSHI1CI，YIRI5CI，FUYONG5TIANYISHANG。

　　3、SHUIDOU：

　　2SUIYISHANGERTONGMEICIKOUFUJILIANGWEI20mg/Kg，MEIRI4CI，ZONGLIANGWEI80mg/Kg/RI。

　　(ER)、JILIANGDIAOJIE：

　　1、JIMANXINGSHENSHUAIHUANZHE：CILEIBINGRENDEYONGFAYUYONGLIANGQINGCANJIANBIAO1

　　2、XUEYETOUXI：DUIYUXUYAOXUEYETOUXIDEHUANZHE，XUETOUQIJIANXUEJIANGZHONGAXILUOWEIDEBANSHUAIQIYUEWEI5XIAOSHI，6XIAOSHIDEXUEYETOUXISHIXUEYAONONGDUXIAJIANG60%，YINCIBINGRENDEYONGYAOJILIANGYINGZAIMEICIDETOUXIHOUYUYIZHUIJIADIAOZHENG。

　　3、FUQIANGTOUXI：WUXUZAIJIYAOQIJIANDIAOZHENGJILIANG。

　　【BULIANGFANYING】

　　1、XIAOHUAXITONGFANYING：BAOKUOEXIN、OUTU、FUXIEDENG。

　　2、GUOMINXINGFANYING：BAOKUOFARE、TOUTONG、WAIZHOUHONGZHONGDENG。

　　3、SHENJINGXINGFANYING：BAOKUOTOUTONG、GUODUXINGFEN、GONGJISHIDIAOZHENG、HUNMI、YISHIMOHU、YISHIJIANTUI、SHENZHICUOLUAN、TOUHUNYANHUA、HUANJUE、JUBUMABI、SHISHUIDENG。

　　4、XUEYEJILINBAXITONG：BAOKUOPINXUE、BAIXIBAOJIXUEXIAOBANJIANSHAODENGZHENG。

　　5、GANDAN、YIXIAN：BAOKUOGANYAN、GAODANHONGSUXUEZHENG、HUANGDANDENG。

　　6、JIROU、GUGEXITONG：JIROUTENGTONGFANYING。

　　7、PIFU：TUOFA、GANGUANGXINGPIZHEN、SAOYANGZHENG、BIAOPIHUAISI、FENGZHENDENG。

　　8、JUBUFANYING：YANBUBUSHIGANDENG。

　　9、QITA：SHENSHUAI、GAOXUENIAODANBAIZHENG、JIGANSHENGGAO、XUENIAODENG。

　　【JINJI】DUIAXILUOWEIGUOMINZHEJINYONG。

　　【ZHUYISHIXIANG】

　　1、JINGGAO：

　　SHENSUNHAIZHEJIESHOUAXILUOWEIZHILIAOSHI，KEZAOCHENGSIWANG。

　　MIANYIGONGNENGBUQUANDEHUANZHEJIESHOUAXILUOWEIZHILIAOSHI，KEFASHENGXUESHUANXINGCHENG、XUEXIAOBANJIANSHAOXINGZIDIAN、RONGXUE、NIAODUZHENGZONGHEZHENG(TT1/HUS)BINGKEDAOZHISIWANG。

　　2、DUISHENGONGNENGYOUSUNSHANGDEHUANZHEYINGDIAOZHENGJILIANG。

　　3、DUIJIESHOUYOUQIANZAIDESHENDUXINGWUZHIDEBINGRENSHIYONGAXILUOWEISHIYINGTEBIEZHUYI，YINWEIZHEIKEYIZENGJIASHENGONGNENGZHANGAIDEWEIXIANXING，YIJIZENGJIAKENIXINGDEZHONGSHUSHENJINGXITONGZHENGZHUANG。

　　4、BINGRENZHUYI：RUGUOGANDAOYOUYANZHONGHUOLINGRENFANNAODEBULIANGFANYING，YIHUAIYUNHUOZHUNBEIHUAIYUNZHE，ZHUNBEIBURUDEFUNV，HUOYOUQITAWENTIDEBINGREN，YINGZIXUNYISHENG，ZAIYISHENGDEZHIDAOXIAHELIYONGYAO。

　　5、MUQIANSHANGWUDAIZHUANGPAOZHENJIXINGFAZUO72XIAOSHICAIKAISHIZHILIAODEYANJIUZILIAO，YINCIDUIYUZHENDUANWEIDAIZHUANGPAOZHENDEBINGRENYINGJINKENENGJIZAOZHILIAO。

　　6、SHENGZHIQIPAOZHENGANRAN：BENPINDUISHENGZHIQIPAOZHENGANRANBUNENGZHIYU。MEIYOUZILIAOZHENGMINGBENPINSHIFOUNENGFANGZHIGAIBINGCHUANRANJITAREN。YINWEISHENGZHIQIPAOZHENSHIXINGCHUANBOJIBING，HUANZHEYINGBIMIANJIECHUHUANCHU，BINGBIMIANXINGJIAO，YIMIANGANRANPEIOU。SHENGZHIQIPAOZHENYENENGZAIMEIYOUZHENGZHUANGSHICHUANRAN，TONGGUOWUZHENGZHUANGDEBINGDUPAICHU。RUGUOFAXIANSHENGZHIQIPAOZHENFUFA，BINGRENYINGGAIZAIDIYIGEZHENGZHUANGHUOTIZHENGSHILIJIZHILIAO。

　　7、SHUIDOU：DUIYUJIANKANGERTONGERYAN，SHUIDOUBIAOXIANWEIZIXIANXINGDEQINGDUDAOZHONGDUJIBING，ERQINGSHAONIANHECHENGRENZEBIJIAOYANZHONG。ZHILIAOYINGZAISHUIDOUJIXINGFAZUO24XIAOSHINEIJINXING，SHANGWUFABINGHOUQICAIKAISHIZHILIAODEYOUXIAOZHILIAOZILIAO。

　　【YUNFUJIBURUQIFUNVYONGYAO】

　　YUNFUSHENYONG。CONG1984NIANDAO1994NIAN4YUEJIANLIDEYIXIANGGUANYUYUNFUSHIYONGAXILUOWEILIAOXIAODELIUXINGBINGXUEJILU，ZAIWEIQI3GEYUEDE756XIANGSHIYANJIEGUOZHONGYOU749MINGYUNFUXIANHOUXITONGFUYONGAXILUOWEI，QIDUIYINGERDEZHIJIZUOYONGJINSIYUPUTONGRENQUN，DANZHEIXIESHUJUSHANGBUZUYIZHENGMINGAXILUOWEIDUIYUNFUHETAIERSHIWANQUANANQUANDE。ZHIYOUDANGAXILUOWEIDUITAIERDEZHILIAOZUOYONGYUANDAYUQIFENGXIANSHICAIKEYIKAOLVFUYONGAXILUOWEI。

　　AXILUOWEIZAIRUZHIZHONGDENONGDUWEIQIXUEYAONONGDUDE0.6-4.1BEI。DANGBURUQIFUNVFUYAOJILIANGDADAOMEITIAN0.3mg/KgSHIKENENGYINGXIANGYINGERDEFAYU。ZHIYOUZAIBIXUQINGKUANGXIA，BURUQIFUNVCAIKEYISHIYONGAXILUOWEI。

　　【ERTONGYONGYAO】2SUIYIXIAXIAOERSHENYONG。

　　【LAONIANHUANZHEYONGYAO】

　　MUQIANSHANGWUCHONGFENDEYANJIUZILIAOBIAOMINGDUI65SUIYISHANGLAONIANRENDEYONGYAOYUNIANQINGRENDEYONGYAOYOUMINGXIANBUTONG。YIBANQINGKUANGLAISHUO，LAONIANRENYONGYAOYINGXIAOXINJINSHEN，XUANZEDIJILIANGDEYOUXIAOFUYAOFANWEI，JINLIANGJIANGDIYINZENGJIAFUYAOCISHUERZAOCHENGDESHENGONGNENGJIANTUIHUOQITAFUFANYINGDEFASHENG。

　　【YAOWUXIANGHUZUOYONG】

　　BINGHUANGSHUYUJINGMAIJIYUAXILUOWEIYIQISHIYONGSHI，AXILUOWEIPINGJUNBANSHUAIQIHEYAOSHIQUXIANXIAMIANJIZENGJIA。

　　【YAOWUGUOLIANG】

　　FUYONGJILIANGDAYU20KE，KEZHIXINGFEN、JIDONG、HUNMI、ZHENZHAN、WULI。KUAISUJINGMAIZHUSHEJIYUGUOGAODEJILIANG，AXILUOWEIHUIYINQIZAISHENXIAOGUANZHONGNONGDUGUODAERJIEJINGJICUN(2.5mg/ml)DAOZHIJISUANGANJIXUENIAOSUSHENGGAOERJIFAYINQIDESHENSHUAI，YIDANFASHENGSHENSHUAIJIWUNIAOZHENG，BINGRENXUZUOXUEYETOUXIZHIZHISHENGONGNENGHUIFU。

　　【YAOLIDULI】

　　YAOLIZUOYONG

　　BENPINWEIHECHENGDEHEGANLEIKANGBINGDUYAO，TINEIHETIWAIDUIDANCHUNPAOZHENBINGDUIXING(HSV-1)、IIXING(HSV-2)JISHUIDOU-DAIZHUANGPAOZHENBINGDU(VZV)JUNYOUYIZHIZUOYONG。XIBAOPEIYANGJIEGUOBIAOMING，BENPINDUIYIZHIHSV-1BINGDUDEZUOYONGZUIQIANG，QICIWEIHSV-2HE VZVBINGDU。

　　YOUYUBENPINDUIYOUHSVHEVZVBIANMADEXIONGGANJIMEI(TK)JUYOUQINHELI，SHIDEQIJUYOUGAOXUANZEXINGDEYIZHIZUOYONG。CILEIBINGDUMEIJIANGAXILUOWEIZHUANHUACHENGAXILUOWEIDANLINSUANYAN，JIHEGANLEISIWU。DANLINSUANYANJINYIBUBEIXIBAOZHONGDENIAOGANSUANJIMEIZHUANHUACHENGERLINSUANYAN，ZAITONGGUOXIBAOZHONGDEDUOZHONGMEIZHUANBIANWEISANLINSUANYAN。ZAITIWAI，AXILUOWEISANLINSUANYANZHONGZHIPAOZHENBINGDUDNADEFUZHISHIYOUYIXIASANZHONGFANGSHIWANCHENG：1)JINGZHENGXINGDIYIZHIBINGDUDNAJUHEMEI;2)JINRUBINGZHONGZHIYANZHANGDEBINGDUDNALIAN;3)MIEHUOBINGDUDNAJUHEMEI。YUVZVXIANGBI，BENPINDUIHSVDEKANGBINGDUHUOXINGGENGQIANG，ZHEISHIYINWEIBINGDUDEXIONGGANJIMEI(TK)DELINSUANHUAZUOYONGGENGQIANG。

　　DULIYANJIU

　　YICHUANDUXING：JINXINGLE16XIANGYICHUANDUXINGSHIYAN，ZAI4XIANGWEISHENGWUYANJIUZHONGWEIJIANZHITUBIANZUOYONG;ZAIXIAOSHULINBALIUXIBAOHERENLINBAXIBAOSHANGJINXINGDE2XIANGTIWAIXIBAOYICHUANSHIYANJIEGUOBIAOMING，BENPINJUYOUZHITUBIANZUOYONG。ZAI5XIANGTIWAIXIBAOYICHUANSHIYAN(3XIANGWEIZHONGGUOCANGSHUDELUANCHAOXIBAO，2XIANGWEIXIAOSHULINBALIUXIBAO)ZHONG，WEIJIANZHITUBIANZUOYONG。ZAIMIANYIGONGNENGBUQUANDE、ZHENGDUANRUDE、TONGYUANDEYOUSHUJIYAOHOUSUOJINXINGDE2CITIWAIXIBAOZHUANHUASHIYANZHONG，QIZHONG1CIJIEGUOWEIYANGXING，KEJIANXIBAOCONGXINGTAISHANGZHUANBIANWEIZHONGLIUXIBAO，ERZAILINGYISHIYANZHONG，ZEWEIJIANTONGYANGDEJIEGUO(YUANYINKENENGSHIMINGANBEIJILIANGJIYAOSHI，RANSETIDESUNSHANGWUMINGXIANBIANHUA);XIAOSHUDEXIANXINGZHISISHIYAN(ZAIRENYONGJILIANGDE36-73BEIJILIANGXIA)JIEGUOWEIYINXING。

　　SHENGZHIDUXING：XIAOSHU(450mg/Kg/TIAN，PO)HEJIATU(25mg/Kg/TIAN，SC)SHIYANJIEGUOBIAOMING，BENPINDUIQISHENGYUNENGLIHESHENGZHIGONGNENGWUYINGXIANG。XIAOSHUHEDASHUDEXUEJIANGYAOWUNONGDUFENBIEWEIRENTIXUEYAOSHUIPINGDE9-18BEIHE8-15BEI。DASHUHEJIATUJIYUGENGGAOJILIANG(50mg/Kg/TIAN，SC，FENBIEWEIRENYONGSHUIPINGDE11-22BEIHE16-31BEI)SHI，KEJIANGDIZHECHUANG，DANBUYINGXIANGTONGWOZIDEDAXIAO。DASHUZAICHANQIANHECHANHOUFUYONGBENPIN(50mg/Kg/TIAN，SC)，ZUJIANPINGJUNHUANGTI、ZONGZHECHUANGWEIZHIHEHUOCUNTAIERDENGJUNYOUTONGJIXUEYIYIDEMINGXIANXIAJIANG。

　　QUANLIANXU1GEYUEJIYUBENPIN(50mg/Kg/TIAN，IV，WEIRENYONGJILIANGDE21-41BEI)(XUEYAONONGDUWEIRENDE21-41BEI)HUOLIANXU1NIAN(60mg/Kg/TIAN，PO，WEIRENYONGJILIANGDE6-12BEI)，JIEGUOJUNWEIFAXIANGAOWANYICHANG。ZAIJIDASHUHEQUANDEGENGGAOJILIANGSHI，KEJIANGAOWANWEISUOHEJINGZIJIANSHAO。

　　XIAOSHU(450mg/Kg/TIAN，PO)、JIATU(50mg/Kg/TIAN，SCHUOIV)HEDASHU(50mg/Kg/TIAN，SC)SUOJIYUDEBAOLUJILIANGFENBIEWEIRENYONGJILIANGDE9-18、16-106、11-22BEISHI，JIEGUOJUNWEIJIANZHIJIZUOYONG。

　　ZAIYUNFUZHONGSHANGWUCHONGFENDEHEYANGEDUIZHAODEYANJIU，DANSHIYOUYILIUXINGBINGXUEDIAOCHAYANJIUBIAOMING，ZHUIZONGLE756MINGYUNFUQUANSHENYONGYAO，DUIYINGERDECHUSHENGQUEXIANFASHENGLVJINSIPUTONGRENQUN。DANZHEIXIESHUJUSHANGBUZUYIZHENGMINGQIDUIYUNFUHETAIERSHIANQUANDE。ZHIYOUDANGBENPINDUITAIERDEZHILIAOZUOYONGYUANDAYUQIFENGXIANSHI，CAIKEYIKAOLVFUYONG。

　　BURUQIFUNVYONGYAO，BENPINZAIRUZHIZHONGDENONGDUWEIQIXUEYAONONGDUDE0.6-4.1BEI。DANGBURUQIFUNVFUYAOJILIANGDADAO0.3mg/Kg/TIANSHI，GAINONGDUKENENGLEIJIYINGER，SUOYIBURUQIFUNVSHIYONGSHIYINGJINSHEN，BINGZHIYOUZAIBIYAOSHICAIKESHIYONG。

　　ZHIAIXING：ZAIDASHUHEXIAOSHUDEZHENGGESHENGMINGQI，TONGGUOGUANSIJIYUBENPIN450mg/Kg/TIAN，JIEGUOBIAOMING，JIYAOZUHEDUIZHAOZUFASHENGZHONGLIUDEDONGWUSHUWUTONGJIXUEYIYIDEXIANZHUCHABIE，YEBUSUODUANZHONGLIUFASHENGDEQIANFUQI。XIAOSHUHEDASHUDEZUIDAXUEJIANGNONGDUFENBIEWEIRENYONGJILIANGSHUIPINGDE3-6BEIHE1-2BEI。

　　【YAODAIDONGLIXUE】

　　JUPhysician’s Desk Reference(54BAN)JIESHAO，AXILUOWEIDEYAODAIDONGLIXUEYANJIUJIEGUORUXIA：JIANKANGZHIYUANZHEJIDANCHUNHUODAIZHUANGPAOZHENHUANZHEKOUFUAXILUOWEIDEYAODONGXUEYIYOUPINGJIA，QIYAODONGXUEJIANBIAO2。

　　JIAOCHASHEJI、DANJILIANGDUOCIKOUFUAXILUOWEIDE23MINGJIANKANGZHIYUANZHEDEYANJIUZILIAOBIAOMING，AXILUOWEIXUEYAONONGDUDEZENGJIAYUJIYAOJILIANGDEZENGJIABUYIZHI(JIANBIAO3)，SHENGWULIYONGDUDEJIANGDIQUJUEYUJILIANGERFEIYAOWUJIXING。

　　6LISHOUSHIZHEDEYANJIUJIEGUOBIAOMING，SHIWUDUIAXILUOWEIDEXISHOUWUYINGXIANG。YINCI，AXILUOWEIKEYUSHIWUTONGFU。JINZHIBENPINNIAODAIXIECHANWUWEI9-((SUOYANGJI)JIAJI)NIAOPIAOLING。

　　TESHURENQUN：

　　SHENGONGNENGSUNSHANGDECHENGREN：AXILUOWEIDEBANSHUAIQIYUZONGXIAOCHULVSHIJIANQUJUEYUSHENGONGNENG。SHENGONGNENGBUQUANDEBINGRENYINGDIAOZHENGJILIANG。

　　ERTONG：AXILUOWEIYIBANZAIERTONGTINEIDEYAODAIDONGLIXUEYUCHENGRENXIANGSI。7GEYUEZHI7SUIDEERTONGKOUFU300mg/m2HE600mg/m2AXILUOWEI，QIPINGJUNBANSHUAIQIWEI2.6XIAOSHI，FANWEIZAI(1.59-3.74XIAOSHI)。

　　YAOWUXIANGHUZUOYONG：BINGHUANGSHUYUJINGMAIJIYUAXILUOWEIYIQISHIYONGSHI，AXILUOWEIPINGJUNBANSHUAIQIHEYAOSHIQUXIANXIAMIANJIZENGJIA，NIAOPAIXIEJIANMAN，NIAOQINGCHULVJIANGDI。

　　【ZHUZANG】MIFENGBAOCUN。

　　【BAOZHUANG】LVSUBANZHUANG。MEIHE24PIAN。

　　【YOUXIAOQI】24GEYUE

　　【ZHIXINGBIAOZHUN】《ZHONGGUOYAODIAN》2005NIANBANERBU

　　【PIZHUNWENHAO】GUOYAOZHUNZIH20054050